Adderall is comprised of multiple amphetamine isomers: dextroamphetamine (~75%) and levoamphetamine (~25%) which called a psychostimulant medication [of the phenethylamine classification]. Adderall is frequently prescribed for the management of ADHD (attention-deficit/hyperactivity disorder) and narcolepsy in medical settings. As an adjunct in the management of refractory neuropsychiatric disorders such as chronic fatigue syndrome; major depressive disorder; and atypical anxiety disorder, Adderall is less commonly utilized off-label.
Additionally, for nonmedical purposes like recreational intoxication and performance enhancement (cognitive or athletic), Adderall is understood and related psychostimulants. The amphetamine isomers dextroamphetamine and levoamphetamine function predominantly via full agonism of TAAR1 receptors and modulation of VMAT2 when administered. To enhances catecholamine signaling throughout the central nervous system, they simultaneously act at TAAR1 and VMAT2.
Generally, users report improvements in attention span and energy due to this catecholaminergic effect. You may be curious as to how long it’ll take for the medication to “kick in” or facilitate a therapeutic effect in the event that you received a prescription of Adderall from a doctor to help manage symptoms of a medical condition. Probably, you’re hoping that as quickly as possible, Adderall will help reduce your symptoms.
How long does it take for Adderall to “kick in” or work?
The effect of Adderall will become noticeable within just 20 to 60 minutes following administration for a majority of users. So, it depends on the particular Adderall user. Adderall’s amphetamine constituents are efficiently and rapidly metabolized, and distributed throughout the body when it is ingested. Adderall immediately begins modulating neurophysiologic targets such as TAAR1 and VMAT2 (in the CNS) and adrenergic receptors (in the PNS) in both the central nervous system and peripheral nervous system.
As well as increased activation of the sympathetic nervous system, this immediate modulation yields increased signaling from catecholamines like dopamine, norepinephrine, and epinephrine. The medication will always start working in less than 1 hour (usually in under 30 minutes), assuming a healthy person takes Adderall as directed – and the medication is properly absorbed, metabolized, and distributed throughout the body.
Not all individuals will be consciously aware of this effect although Adderall will always “kick in” or facilitate an effect in just minutes after administration. Within an hour of administration, users who don’t notice its effect may question whether the medication is really working. To psychostimulants, two variables will be most influential in determining whether you’re able to consciously detect Adderall working: dosage administered and degree of tolerance in most cases.
After administration, to psychostimulants, someone may have a difficult time detecting the effect of Adderall anh they exhibits high tolerance and/or who ingests a tiny dose of Adderall. On the other hand, may notice the medication “kick in” very rapidly for a person without any preexisting tolerance to psychostimulants and/or who ingests a high dose. It shows that does not mean that the medication hasn’t taken effect, just because you don’t consciously notice Adderall working.
It might be to blame if you don’t notice Adderall working, variables such as concurrent substance use; intestinal pH; preexisting medical conditions; and low self-awareness. Besides, Adderall working on the first day – or even week of treatment due to inadequate dosing and/or lack of medication-induced changes in neurophysiology (e.g. nerve growth) that are only attained with longer-term treatment, but some individuals may not notice.
In other words, because they start treatment with too low of a dose – and need to titrate or increase the dosage to notice an effect, some individuals may not notice Adderall working. Moreover, for some individuals derive maximal therapeutic benefit from Adderall, neurophysiologic adaptations that can only be attained with longer-term use may need to occur.
Note: Not everyone will derive therapeutic benefit from Adderall because one of the users may claim that the medication failed to manage unwanted symptoms of a medical condition (e.g. ADHD). Adderall always “works” in terms of exerting a neurophysiologic effect, although it sometimes won’t “work” for the management of medical symptoms, it always “works” in terms of exerting a neurophysiologic effect.
Notice that medication working right away – from 20 to 60 minutes of administration for the majority of Adderall users. Really notice that the medication has “kicked in” after several consecutive days of administration although others may not fully notice the effect of Adderall on the first day of treatment.